健身运动处方锻炼对男大学生心泵功能与血压的影响

影响体质与健康的重要因素之一是心血管功能。纵观全国三次大规模的大学生体质测试结果,都显示大学生心功能有下降的趋势。因此,如何有针对性的通过体育锻炼提高大学生心血管功能,是我们应该重视并尽快解决的问题。本研究研制不同性质的健身运动处方,指导男大学生进行课外体育锻炼,观察不同性质健身运动处方锻炼对心血管功能的影响。结果表明:本研究制定的速度、耐力、篮球、足球、排球与全面锻炼6套健身运动处方对增强男大学生的心泵血功能有较强的作用,力量、耐力、健美操及排球运动处方对改善血管功能有较好的效果。     

Angiotensin Converting Enzyme Gene Polymorphism and its Association with Hypertension in South Indian Population

Hypertension, a well known risk factor for various cardiovascular, peripheral vascular and renal events is an important public health challenge. Renin angiotensin system (RAS) being the most vital pathogenic mechanism of hypertension is mediated by a key component; the angiotensin converting enzyme (ACE). The present study was aimed to know the relationship of ACE gene polymorphism and the possible risk of development of hypertension in south Indian population. The study included 101 clinically diagnosed hypertensive patients without any associated disease condition and 81 age and sex matched apparently healthy controls. Genotyping was performed using a polymerase chain reaction, (PCR) amplification of the intron 16 fragment harboring the 287 bp Alu repeat sequence. Three possible genotypes D/D, I/I homozygous and I/D heterozygous were analyzed where the D/D genotypes corresponds to higher ACE levels (D-Deletion, I-Insertion). The PCR products were separated on 2 % agarose gel. Statistical analysis was performed using SPSS.15 software program. We found a significance in frequency of D/D genotype in the hypertensive patients compared to the control group (p = 0.0005, odd’s ratio = 4.157). This suggested that ACE (D/D) genotypes are more prone for the development of hypertension. This is relatively a pilot study; but nevertheless may assist in identifying the pathophysiological cause of hypertension.     

Relation of uric acid levels to aortic root dilatation in hypertensive patients with and without metabolic syndrome

Objective:Uric acid(UA) is considered to be a powerful predictor of cardiovascular risk and hyperuricemia might be involved in the metabolic syndrome(MS).This study aims to investigate the relation between UA levels and aortic root dilatation.Methods:A total of 348 hypertensive patients [age(67.5±9.8) years] with or without MS were included in the study.The aortic root diameters at the aortic annulus,the sinuses of Valsalva,the sinotubular junction,and the proximal part of the ascending aorta were measured using a two-dimensional(2D) echocardiography.Serum UA levels were also measured for all patients.Results:A high UA level is independently associated with aortic root diameters at the sinuses of Valsalva(P=0.001) and the proximal ascending aorta(P0.0001) in the hypertensive patients without MS.In contrast,aortic root diameters were not significantly related to UA levels in the hypertensive patients with MS.Furthermore,increased UA levels were associated with an increased risk for aortic root dilatation in the patients without MS(sex-adjusted hazard ratio 1.75,95% confidence intervals(CI) 1.27-2.41),but not in those with MS.Conclusions:This study demonstrated an independent relationship between the aortic root dimensions and increased levels of serum UA in the hypertensive patients without MS.Further understanding of the mechanisms underlying these associations may allow a clearer interpretation of the potential value of specific urate-lowering treatment on cardiovascular disease.     

海口市社区高血压患者自我管理现状调查

目的了解海口市社区高血压患者自我管理行为现状。方法在海口市龙华区的两个社区中随机抽查218名原发性高血压患者,采用自编高血压患者自我管理调查问卷进行调查。结果 45.4%的患者不能做到低钠饮食,30.3%的患者常食用脂肪含量较高的食物;48.2%的患者不遵医嘱用药,54.7%的患者不能坚持长期用药;63.3%的患者一般不会向朋友家人倾诉,36.7%的患者不能做到情绪稳定;62.4%的患者常常出现头晕,64.2%的患者时常出现失眠,76.1%的患者常出现肢体麻木;49.1%的患者没能做到经常适量运动。结论海口社区高血压患者在饮食、用药、运动、症状及情绪的自我管理方面总体水平不高。     

尼可地尔与康宝得维联用治疗老年高血压病患者疗效的观察

目的：探讨尼可地尔与康宝得维联用对老年人高血压的疗效。方法：选择200例60岁以上高血压病患者，血压均为1～2级，病史在10年以上，心功能在Ⅱ级以上（NYHA分级法），采用随机对照临床实验的系统评估分析。随机分两组，观察组100例，口服康宝得维（国产非洛地平缓释片）5～10mg，每日早晨口服一次，尼可地尔5～10mg，每日三次；对照组100例，口服康宝得维5～10mg，每日早晨口服一次。治疗前后分别检测心功能、颈动脉壁内中膜厚度，检测肾功能、血脂、空腹血糖、餐后2h血糖等生化指标，两组结果进行对比研究．结果：康宝得维与尼可地尔联用明显降低老年高血压患者血压、明显改善心功能，较对照组有显著性差异（P〈0．01）；两组均能改善血糖水平及肾功能指标，较治疗前有显著性差异（P〈0．01）。结论：康宝得维是安全、降压效果好而不良反应少的降压药物，与尼可地尔联合能明显改善心功能，尤其适合高血压病合并冠心病、心功能不全、肾功能不全、动脉硬化、2型糖尿病的患者，更适合于60岁以上老年人高血压长期应用。     

Influence of HbA1c on short-term blood pressure variability in type 2 diabetic patients with diabetic nephropathy

The aim of this study was to understand the characteristics of blood pressure(BP)variability in subjects with diabetic nephropathy(DN),and identify the probable predictors affecting BP variability.Fifty-one chronic kidney disease(CKD)-hypertensive patients without diabetes(NDN group)and sixty type 2 diabetic patients with overt DN(DN group)were enrolled in this study.The values of short-term BP variability were obtained from 24 h ambulatory BP monitoring(ABPM).Variance analysis or nonparametric analysis revealed that 24-h systolic BP variability and nighttime systolic BP variability of the DN group were significantly higher than those of the NDN group[(12.23±3.66)vs.(10.74±3.83)mmHg,P<0.05;(11.23±4.82)vs.(9.48±3.69)mmHg,P<0.05].Then the patients of the DN group were divided into two groups according to glycated hemoglobin(HbA1c)level:Group A(HbA1c<7%)and Group B(HbA1c≥7%),and the t-test showed that patients in Group B had larger 24-h diastolic,daytime diastolic,and nighttime systolic/diastolic BP variability compared with Group A.In the DN group,partial correlation analysis revealed that HbA1c exhibited a strong association with 24-h diastolic,daytime diastolic,nighttime systolic and diastolic BP variability(P<0.001,P<0.001,P<0.05,and P<0.001,respectively).Taken together,larger short-term BP variability was detected in hypertensive type 2 diabetic patients with overt nephropathy and renal insufficiency.It may imply that the optimal BP variability level could benefit from a better glycaemic control.     

高血压患者心功能变化的研究

目的研究高血压患者心功能的变化.方法常规心阻抗测定方法采用日本RM-6000多导生理记录仪.结果对394例心功能检查的结果进行分析高血压组检测SV、CO、CI、AC均明显低于正常,原发性高血压患者和临界高血压患者的SV、CO、CI、AC、TPR则无显著性差异.结论高血压患者在血压病理性升高过程中,早期心功能即发生异常变化,并在发展成高血压后一定时期内心功能保持稳定.     

Study of clinical features of amyloid angiopathy hemorrhage and hypertensive intracerebral hemorrhage

Objective: The purpose of this study was to differentiate between cerebral amyloid angiopathy (CAA) and hypertension (HTN) based on hemorrhage pattern interpretation. Methods: From June 1994 to Oct., 2000, 83 patients admitted to our service with acute intracerebral hemorrhage (ICH) were investigated retrospectively; 41 patients with his-tologically proven diagnosis of cerebral amyloid angiography and 42 patients with clear history of hypertension were investigated. Results: Patients with a CAA-related ICH were significantly older than patients with a HTN-related ICH (74.0 years vs 66.5 years, P<0.05). There was a significantly higher number of hematomas>30 ml in CAA (85.3%) when compared with HTN (59.5%). No basal ganglional hemorrhage was seen in CAA, but in 40.5% in HTN. In CAA-related ICH, su-barachnoid hemorrhage (SAH) was seen in 26 patients (63.4%) compared to only 11 patients (26.2%) in HTN-related ICH. Intraventricular hemorrhage was seen in 24.4% in CAA, and in 26.2% in HTN. Typical features o     

高血压中医证型与血液指标的相关性研究进展

近些年来关于高血压中医证型与客观血液生化指标的相关性研究广泛开展并已取得一些进展,血液指标能反映出高血压中医辨证分型的分布规律,文章就高血压中医证型与血液指标的相关性研究作一综述,但由于采用的证型缺乏统一性,与高血压发病密切相关的一些血液指标与中医证型相关性研究仍缺乏可比性。     

基于BP神经网络的高血压诊疗预测分析

本文对72例高血压临床数据展开研究,通过BP神经网络结合临床数据中包含的中医西医的检查结果,对高血压病诊断结果的等级分层和用药情况进行预测分析,通过对10例预测样本分析,达到了88%的准确度,并对不同的BP神经网络函数进行比较,找到效果更优的函数设置。