Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.     

Digital Module 05: Diagnostic Measurement—The G‐DINA Framework https://ncme.elevate.commpartners.com

In this ITEMS module, we introduce the generalized deterministic inputs, noisy “and” gate (G‐DINA) model, which is a general framework for specifying, estimating, and evaluating a wide variety of cognitive diagnosis models. The module contains a nontechnical introduction to diagnostic measurement, an introductory overview of the G‐DINA model, as well as common special cases, and a review of model‐data fit evaluation practices within this framework. We use the flexible GDINA R package, which is available for free within the R environment and provides a user‐friendly graphical interface in addition to the code‐driven layer. The digital module also contains videos of worked examples, solutions to data activity questions, curated resources, a glossary, and quizzes with diagnostic feedback.     

谈谈高校外文图书采访改革

外图书采访一直是高校图书馆献资源建设的重点之一，结合本馆外图书采访的实际工作经验，提出改革外图书采购模式的若干看法。     

原版外文期刊下架的几个原则

探讨了原版外期刊下架过程中应掌握的几个原则：按分类顺序或按架面拥挤程度合理地选择下架方式；分清正题名、分辑名副题名等，正确勾画刊名；根据正刊、副刊、增刊、特刊、别册的特点，正确区别正刊与附件；按年、卷、期顺序确定合适的下架合订本厚度。     

如何帮助大学生渡过英语学习转型期

中学外语教育在分数和升学的压力下,学生自觉或不自觉地采用了不恰当的学习方法,给后继教育增加了困难,大学教师要尽早发现新生学习中存在的问题,纠正学生对外语学习不正确的认识和不良的学习习惯,以适应大学阶段及更长效的学习。     

高校体育教育专业实践课的英文教学

在华南师范大学体育教育专业团体操选修课的实践课中实施英文教学，两轮英文教学实验不仅没有影响专业课的教学质量，还有助于提高学生学习英语的积极性和教师应用英语进行专业课教学的能力。     

论第四种情报检索语言系统

第四种情报检索语言是自然语言与人工语言结合的一体化语言。第四种情报检索语言系统是一种基于网络的信息检索系统 ,比分类主题一体化情报检索语言系统更高级更新颖 ,是我国 2 1世纪情报检索语言系统研究的方向。加快我国第四种情报检索语言系统研究的关键 ,是解决汉语分词技术问题。参考文献 14。     

Does the Model of Language in the National Literacy Strategy Create Failure for Pupils from Differing Language Backgrounds?

The National Literacy Strategy (NLS) was introduced by the government in the wake of the hotly debated issue of falling educational standards in the UK. All schools were required to adopt the NLS Literacy Hour unless they could show their preferred programme would result in raised levels of achievement. My experience of delivering the Literacy Hour has been a process of adaptation to the needs of my pupils, who are drawn mainly from groups whose language backgrounds differ from that which is dominant in school. I have found that the requirements of NLS, together with many of the commercial resources used to teach it, are not appropriate for pupils from these groups and a question arose: is it the pupils who are in some way deficient or is it the approach and the resources being used? This article takes a case study of the use of a commercially produced resource to explore the model of language implicit in NLS, the kinds of resources it generates and the ways in which this creates failure in pupils from different language backgrounds. It then considers the New Literacy Studies and their implications for an alteration in our approach.     

普通话教学的心理学基础

普通话教学的心理学基础主要由语言心理学和教育心理学两方面的相关研究构成。 心理学理论对普通话教学的指导有两种表现,一是根据学生言语形成的特点,提供教学依据;二是 运用心理学研究的学习原理来提高普通话教学的质量。     

艺术语言在中学语文教材中的运用

中学语文教材的内容，从语言表现形式上看，是由艺术语言和科学语言组成。由于艺术语言的大量存在，使语文学科具有了人文性的特点，也有了不同于其他学科的独特的美。