Rotenone induces more serious learning and memory impairment than α-synuclein A30P does in Drosophila

Parkinson’s disease (PD) is a heterogenous disease caused by multifactorial etiology. PD is characterized by the loss of dopaminergic (DA) neurons in the substantia nigra and the accumulation of Lewy bodies. In this study, two Drosophila PD models by exposing Drosophila to rotenone (sporadic PD models) are proposed, and the human α-synuclein A30P protein (family PD models) in Drosophila is expressed respectively. Both models recapitulated the main human PD symptoms including the loss of dopaminergic neurons...     

无限的关爱

有一天,妈妈在学校里突然生病了,爸爸知道后,马上接妈妈回了家,安顿好妈妈后,又急急忙忙来到学校接我。我在路上想:不知道妈妈生了什么病,连班都不能坚持上完,我可真要赶快回家看看。我回到家,连鞋子也顾不得脱,就来到妈妈的房间,急切地问:“妈妈,你的身体还好吗?”妈妈有气无力地说:“不太好。”我又问:“你哪儿不舒服?”妈妈说:“我头晕、难受。”“那好,妈妈,你好好休息,我要做作业了,不用惦念我。”我悄悄地关上门,轻手轻脚地走到了自己的房间,认真地做起了作业。我想让妈妈看到我的作业能会心地一笑,让妈妈减轻一点生病的痛苦。我做好…